The results of Yueting Wang et al. showed that GSK 3βsiRNA and the inhibitor (SB216763) alleviated cerebral I/R injury in rat, which was ischemia for 1 h and then reperfusion for 24 h by improving neurological scores, reducing the cerebral infarct volume and decreasing the levels of NLRP3 inflammasome, cleaved caspase-1 IL-1β and IL-18. This evidence concerns the gene NLRP3 and ischemia.