HMOX1 and dry eye syndrome: Nrf2-siRNA/HO-1-siRNA abolished the effects of lycopene on autophagy and the NLRP3 inflammasome activation, indicating that lycopene could improve hepatic I/R injury through inhibiting the NLRP3 inflammasome activation by promoting autophagy via activating the Nrf2/HO-1 pathway in KCs [86].