EGF inhibits CAV1 and influences a large number of genes, such as ITGB1, VCL, COL1A1, IL6, CXCL8, CTGF, MKI67, ERK1, ERK2 and RELA. The low EGF gene expression of the FTC-133 cells cultured in space might explain the downregulation of these genes in AD and MCS. The gene discussed is CCN2; the disease is Alzheimer disease.