NFE2L2 and Other metabolic disease: Taking into account the ability of MOTS-c under different metabolic stresses to translocate to the nucleus and regulate the expression of many genes, primarily with ARE (antioxidant response elements) and TF (such as NFE2L2/NRF2 (nuclear factor erythroid 2-related factor 2)) [21], it could be considered as a crucial player in the metabolism of glycolipids and a promising target for the treatment of metabolic diseases.