TNF and neoplasm: For example, resolvins and lipoxins are SPMs that can be naturally synthesized from AA, docosahexaenoic acid and aspirin, and perform potent proresolving and anti-inflammatory functions by regulating the infiltration of immune cells, removing apoptotic cell debris, inhibiting the synthesis of proinflammatory cytokines (e.g., TNF-α, IL-6, CXCL10, COX-2, and MCP-1), and inhibiting tumor migration/metastasis [32,191,192,193,194].