Increasing evidence has shown that the hallmarks of SS are uncontrolled inflammation (e.g., IFNγ, IL-1β, IL-6, and IL-17) and elevation of autoantibody (i.e., Ro/SSA and La/SSB) production found in the exocrine glands, and that these pathological responses are directly influenced by sex hormones [25,119,120,121,122,123,124,125,126,127,128,129,130,131]. The gene discussed is IFNG; the disease is synovial sarcoma.