ESR1 and chronic rhinosinusitis with nasal polyps: Although the underlying role of estrogens in regulating the resolution of uncontrolled inflammation in CRSwNP remains largely unknown, ER polymorphism has been implicated in female airway hypersensitivity and asthma through regulation of the activities of eosinophils, and the regulatory machinery might also play a role in resolving CRSwNP [58,59].