The infiltration of inflammatory cells in oral submucous fibrosis mainly comprises lymphocytes, plasma cells, and macrophages, which are altered by tumor cells to produce proinflammatory cytokines (i.e., TNF-α, IL-8, and IL-6), prostaglandins, COX-2, and ROS, elevating the inflammatory status in the local microenvironment, which favors tumor growth [186,187,190]. The gene discussed is CXCL8; the disease is neoplasm.