Consistent with this, treatment of RHE with THDC alone (but not THDC + AZ) led to up-regulation of genes belonging to the “unhealthy skin signature” [52] (Figure 5A) as well as the STAT1-57 gene module (Figure 5K), which is also activated under pathological conditions such as wounding and skin cancers [53]. The gene discussed is STAT1; the disease is skin cancer.