Other upregulated genes were related to myeloid cell lineage commitment (Irf8) [14], myeloid/macrophage function (Il1a, Il1b, Osm), cellular mobility (Tspan7), as well as Cd38, which can be expressed by macrophages and correlates with improved outcome as observed in liver cancer [15], but can also function to breakdown ADP and suppress T cells’ function [16] (Figure 1C). The gene discussed is IRF8; the disease is liver cancer.