These results are in keeping with recent IHC studies correlating EGFR overexpression and unfavorable clinico-pathological features of CCRCC, such as tumor size and SSIGN score [11], high tumor grade and stage, poorly differentiated tumors, poor prognosis [10,29,31,32,33], invasion [30], large tumor size and shorter survival [33]. This evidence concerns the gene EGFR and neoplasm.