Numerous factors are at the heart of the metabolic rewiring that occurs in tumors (including acute leukemias), amongst which a key role is played by signaling pathways frequently deregulated in cancer such as avian myelocytomatosis viral oncogene homolog (MYC), neurogenic locus notch homolog protein 1 (NOTCH1), Fms Related Receptor Tyrosine Kinase 3 (FLT3), rat sarcoma viral oncogene homolog/mitogen-activated protein kinase (RAS/MAPK), and the phosphoinositide 3-kinase (PI3K)/v-akt murine thymoma viral oncogene homolog (AKT)/mechanistic target of rapamycin (mTOR) pathways [6]. The gene discussed is NOTCH1; the disease is cancer.