EZH2 and myeloproliferative neoplasm: In fact, a recent study demonstrated that mutations in Ras, such as the G12D mutation, together with loss of function mutations of Enhancer of zeste homolog 2 (Ezh2) cooperate to induce leukemic transformation in mice with myeloproliferative neoplasms (MPN) due to epigenetic and metabolic reprogramming.