KMT2A and leukemia: In breakpoint cluster region-Abelson murine leukemia viral oncogene homolog (BCR-ABL) and mixed-lineage leukemia-ALL1 fused gene from chromosome 9 (MLL-AF9) rearranged leukemia models, the deletion of pyruvate kinase M2 (Pkm2) or lactate dehydrogenase A (Ldha) in HSCs delays leukemia development, supporting the concept of active glycolysis as an important factor for leukemia initiation [35].