In addition, this study showed that the deprivation of Asn specifically determined a significant induction of zinc finger and BTB domain containing 1 (ZBTB1), which is a transcription factor involved in T cell development [117,118], whose loss was sufficient to sensitize resistant T-ALL cells to ASNase both in vitro and in vivo. Here, ZBTB1 is linked to acute lymphoblastic leukemia.