The KCNIP2 (potassium channel interacting protein 2), which interacts with the subfamily of voltage gated potassium channel (Kv4), regulating cardiomyocyte currents, has been shown to be regulated by Notch signaling in mouse models of heart failure, whereby downregulation of Kcnip2 is correlated with a loss of H3K4me3 associated with dynamic RBP-J binding to the Kcnip2 promoter [60]. The gene discussed is KCNIP2; the disease is heart failure.