Another histone methyltransferase which has been implicated in DCM is DOT1L, which catalyzes the methylation of H3 at lysine 79 (H3K79me); expression of DOT1L is decreased in DCM hearts, and a murine knockout model of DOT1L has been associated with a DCM phenotype [49]. Here, PRDM9 is linked to familial dilated cardiomyopathy.