NLRP3 and Alzheimer disease: On the other hand, the differences in the immunodetection of NLRP3 in their results versus ours may be due, not only to different tissue processing and immunohistochemical procedures but, more importantly, to the use of a different animal model of AD, since our results were obtained from 22 month-old single-mutated APPswe mice, while Heneka et al., 2013, analyzed 16 month-old double-mutated APPswePSEN1dE9 mice.