Characteristic for a potent Th1-oriented tumor-associated antigen (TAA) specific adaptive immune response is the presence of immunogenic TAAs, presented via MHC-I on the surface of tumor cells, together with Fas, TRAIL, and IFN-γ receptors and the presence of perforin, granzymes, IFN-α/β/γ, IL-1, IL-12, and TNFα within the TME. Here, TNF is linked to neoplasm.