Domatinostat is a histone deacetylase inhibitor, which leads to G2/M cell cycle arrest and initiates apoptosis in MCC cell lines showed by Song et al. Additionally, they observed an up-regulation of MHC I on the surface, which might result in higher presentation of neo-antigens on MHC and therefore a better anti-tumour T-cell response. This evidence concerns the gene HLA-C and neoplasm.