ITGAX and obesity due to melanocortin 4 receptor deficiency: Perf-DC was identified as the distinct tolerogenic subset of ATDCs in obesity by using Itgax-DTA-Prf1−/− chimera HFD mice, where CD11c+ Perf+ DC depletion exacerbates metabolic parameters such as body weight, VAT weight, liver weight, liver triglycerides, leptin level, insulin level, and also proinflammatory cytokine secretion, including IL-1β and TNFα [56].