In this mini-review, we discuss the role of UPRs in renal diseases and renal fibrosis, highlight the therapeutic potentials of the modulation of UPRs and the proteostasis of ER, and, in particular, emphasize the role of inositol-requiring protein 1-X-box-binding protein 1 (IRE1-XBP1) signaling. Here, ERN1 is linked to renal fibrosis.