Furthermore, Fan and Xiao et al. showed that the dysregulation of UPRs was correlated to the severity of the progression from AKI to CKD in humans, with upregulated expression of Bip, p-PERK, and CHOP and reduced expression of XBP1s in patients with progressive AKI renal biopsy [71]. The gene discussed is EIF2AK3; the disease is acute kidney injury.