MTOR and Anxiety: The appearance of anxiety in these studies compared to the lack of effect observed in our study could be due (1) to the systemic administration of mTOR inhibitors (compared to our local knockdown), (2) to the use of a wider battery of behavioral tests (including the elevated plus maze) [41,52], or (3) to the temporal appearance of this behavior, as some authors study the long-term behavioral effect [41,52,57] (compared to our acute studies).