The acute mTOR downregulation in the IL cortex leads to reduced BDNF mRNA levels in mPFC, together with impaired 5-HT and glutamate neurotransmission in the DRN, disturbances linked to neuropathophysiology of depression, as reported in preclinical [31,36,48,49] and clinical [50] studies. The gene discussed is BDNF; the disease is major depressive disorder.