Therefore, mutations or disturbances in E3 ubiquitin ligase (Parkin), α-syn, a parkin-associated protein involved with oxidative stress (DJ1), ubiquitin carboxy-terminal hydrolase L1 (UCHL1), auxilin (DNAJC6), putative serine-threonine kinase (PINK1), synaptojanin 1 (SYNJ1), serine peptidase 2 (HTRA2), and endophilin A1 (SH3GL2) disrupt several mitochondrial functions and may cause PD development [12]. This evidence concerns the gene PRKN and Parkinson disease.