Moreover, albanol B, a benzofuran flavonoid, exerted potent anti-cancer effects by inducing apoptosis through mtROS production and associated increased phosphorylation of Akt and extracellular signal-regulated kinase 1/2 (ERK1/2) in A549, BZR, H1975, and H226 human lung cancer cell lines. This evidence concerns the gene MAPK3 and lung cancer.