In addition to APOE ε4, several gene variants, including BIN1, ABC7, PICALM, MS4A4E/MS4A6A, CD2Ap, CD33, EPHA1, CLU, CR1, and SORL1, were also found to be associated with Aβ accumulation and linked to late-onset AD [307]. The gene discussed is APOE; the disease is Alzheimer disease.