The clustering revealed three dominant HCC cell clusters (Figure 1A): EpCAM-negative and CD90-positive HCC cells (hereinafter ‘CD90+ cell cluster’), EpCAM-positive and CD90-negative HCC cells (‘EpCAM+ cell cluster’) and EpCAM-negative and CD90-negative HCC cells (‘Neutral cell cluster’). The gene discussed is EPCAM; the disease is hepatocellular carcinoma.