We generated a human neural cell culture model of AD that mimicked AD pathology by overexpressing the human amyloid precursor protein with both Swedish (K670N/M671L) and London (V717I) FAD mutations in the SH-SY5Y cell line, referred to as FAD cells, to investigate the correlation between class IIa HDACs and Aβs. This evidence concerns the gene PSEN1 and Alzheimer disease.