The following are the names of the hub genes: UBC, UBA52 (over-expressed during hepatoma cell apoptosis), RPS27A (cell malignant transformation), RPS3 (cell apoptosis regulation), FAU (down-regulated in human prostate, breast, and ovarian cancers), RPL7 (cell apoptosis regulation), RPL23A, RPL4 (self-translation regulation—E. The gene discussed is UBC; the disease is hepatocellular carcinoma.