While PDK1 is less sensitive to DCA than PDK2 or PDK4 (PDK2 > PDK4 > PDK1 > PDK3) [3], DCA reduced the abundance of PDK1 in cancer cells [12,30] and fibroblasts [31], indicating that inhibition is not the only mechanism by which DCA reduces the PDK1 function. The gene discussed is PDK2; the disease is cancer.