In addition to this, changes in microRNA expression as demonstrated for miR-326-3p and miR-3547-3p can affect key splicing regulators like Srrm4. Comparatively, the role of miRNAs in the regulation of alternative splicing of tau was investigated in the brain, and their changes were shown to associate with the development of Alzheimer’s disease [50]. The gene discussed is SRRM4; the disease is early-onset autosomal dominant Alzheimer disease.