As GLUT4 expression is much decreased in insulin-resistant state and T2DM, potent stimulators of GEF and MEF2 can be used as an alternative treatment to enhance GLUT4 expression for improved insulin sensitivity as experimentally demonstrated in some research studies through the use of GLUT4 overexpression in murine skeletal muscle [70,77,78]. This evidence concerns the gene INS and type 2 diabetes mellitus.