The PathwayGuide Analysis (Table 5; p < 0.05 using Fisher’s method) further predicted that top pathways in primary RGC degeneration (RT vs. LT) may be related to ferroptosis, the HIF-signaling pathway, the adipocytokine signaling pathway, necroptosis, and cell adhesion molecules, whereas secondary RGC degeneration (RN vs. LN) may be related to complement and coagulation cascades, hepatitis B, the Jak-STAT signaling pathway, pancreatic cancer, and serotonergic synapse. This evidence concerns the gene SOAT1 and familial pancreatic carcinoma.