Numerous regulated proteins shared by the two rat models of pONT and IOP elevation via microbead injection include AHNAK, APOE, FGB, KNG1, NDUFA2, GSTM5, and members of S100, crystallin, CPLX, and ANXA families, providing evidence that the mechanisms underlying the progressive RGC degeneration after pONT injury are relevant to glaucoma. Here, APOE is linked to glaucoma.