In CLL and NHL cells, IMiDs and CELMoDs re-target cereblon-dependent activity by promoting the recruitment and its selective binding to two haematopoietic transcription factors Ikaros (IKZF1) and Aiolos (IKZF3), resulting in their ubiquitination and subsequent proteasomal degradation. This evidence concerns the gene IKZF3 and non-Hodgkin lymphoma.