IKZF1 and B-cell chronic lymphocytic leukemia: In CLL and NHL cells, IMiDs and CELMoDs re-target cereblon-dependent activity by promoting the recruitment and its selective binding to two haematopoietic transcription factors Ikaros (IKZF1) and Aiolos (IKZF3), resulting in their ubiquitination and subsequent proteasomal degradation.