In CLL and NHL cells, IMiDs and CELMoDs re-target cereblon-dependent activity by promoting the recruitment and its selective binding to two haematopoietic transcription factors Ikaros (IKZF1) and Aiolos (IKZF3), resulting in their ubiquitination and subsequent proteasomal degradation. The gene discussed is IKZF1; the disease is non-Hodgkin lymphoma.