INS and Hyperglycemia: The soybean-derived bioactive peptide aglycin, was effective in controlling hyperglycemia and improving glucose tolerance by restoring insulin signaling transduction through the maintenance of IR and IRS expression at both the transcriptional and translational levels, as well as enhancing the expression of phosphorylated IR (p-IR), p-IRS1, p-Akt, and GLUT4 in C2C12 cells and in streptozotocin/HFD-induced diabetic BALB/c mice (Table 1).