TSC1 and lymphangioleiomyomatosis: An attempt to reprogram LAM lung cells were developed by the induced pluripotent stem cell (iPSC) lines that demonstrated normal TSC2 and TSC1 expression, suggesting that TSC2 deficiency inhibited the production of iPSC lines LAM iPSC, as defined by TSC2 mutation, but do not seem to grow as a clonal population in cell culture [38].