TSC2 and lymphangioleiomyomatosis: To this point, the establishment of human lymphangioleiomyomatosis cell models have been attempted from LAM patients, after biopsy or transplant, grown as a mixture of TSC2 wild-type and TSC2-null cells, with increased activation of mTOR [35,36,37], but the pure clonal population of TSC2-null pulmonary cells has not been established.