Here, we consider the effect of cyclic compounds and their conjugates on the amyloid formation of pro-inflammatory S100A9 protein, which was found to be a common denominator in Alzheimer’s and Parkinson’s diseases as well as in traumatic brain injury, which is considered to be a pre-cursor state for neurodegenerative ailments [11,12,13]. This evidence concerns the gene S100A9 and Parkinson disease.