IL-6 induces insulin resistance in the liver through the activation of signal transducer and activator of transcription 3 (STAT3) and the subsequent induction of suppressor of cytokine signaling 3 (SOCS3), which inhibits insulin signaling by interfering with insulin receptor activation, blocking IRS activation, and inducing IRS degradation [72]. This evidence concerns the gene IARS1 and Insulin resistance.