The upregulated genes were particularly enriched in the following top ten pathways: focal adhesion (17 proteins), human papillomavirus infection (16 proteins), PI3K-Akt signaling pathway (15 proteins), extracellular matrix-receptor interaction (14 proteins), metabolic pathways (13 proteins), pathways in cancer (13 proteins), complement and coagulation cascades (11 proteins), regulation of actin cytoskeleton (10 proteins), lysosome (10 proteins), and rheumatoid arthritis (9 proteins). Here, AKT1 is linked to rheumatoid arthritis.