Genetic analyses performed in cBioPortal (https://www.cbioportal.org, accessed on 2–12 May 2021) [56,57] reveal that the three members are somatically altered in 12 common cancer types (Figure 3A), and that non-synonymous mutations are rare, typically occurring in ≤1% of cancers for SKP1 and RBX1 or ≤5% for CUL1 [58]. This evidence concerns the gene CUL1 and cancer.