Conversely, copy number gains (gains plus amplifications) for SKP1, CUL1, and RBX1 range from 3% (uterine) to 31% (liver), 12% (cervical) to 80% (glioblastoma), and 1% (prostate) to 22% (head and neck), respectively. The gene discussed is CUL1; the disease is glioblastoma.