CUL1 and neoplasm: In agreement with the predominant copy number alterations detailed above, mRNA expression analyses performed using the In Silico Transcriptomics (IST) database (https://ist.medisapiens.com, accessed on 2–12 May 2021) [94] reveal considerable variation in SKP1 (ENSG00000113558) and CUL1 (ENSG00000055130) mRNA expression in normal and tumor tissues (Figure 5A); unfortunately, no RBX1 expression data are available.