Beyond somatic mutations, SKP1, CUL1, and RBX1 gene copy number alterations including deep deletions (loss of 2 alleles), shallow deletions (loss of 1 allele), gains (gain of 1 allele), and amplifications (gain of ≥2 alleles) are frequently observed in all 12 cancer types (Figure 3C). Here, CUL1 is linked to cancer.