CUL1 and neoplasm: Importantly, while the copy number alterations detailed above suggest SKP1, CUL1, and RBX1 may harbor tumor suppressor- and/or oncogene-like properties, these outwardly contrasting activities have also been described for many well-established cancer-associated genes including BTRC [56,57,58], TP53 [89,90,91], RAD54B [92], and USP22 [93].