SKP2 and melanoma: Interestingly, siRNA-based silencing of SKP2 in melanoma cells causes increases in P27 abundance and growth suppression, both in in vitro and in vivo mouse models [67], while SKP2 knockout mice exhibit increases in cyclin E and P27 expression levels, polyploidy, supernumerary centrosomes, proliferation defects, and increases in apoptosis [13].