Colosetti et al. used the chronic myeloid leukemia (CML) cell line K562 to prove that autophagy induction is an important event for megakaryocytic differentiation and is also accompanied by increased expression of Beclin 1 and p62/sequestosome 1 (SQSTM1) [32]. Here, SQSTM1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.