On the other hand, Li et al. demonstrated that Cullin4B (CULB4) (a scaffold protein of the CUL4B-RING E3 ubiquitin ligase complex, highly expressed in DLBCL) is implicated in the positive regulation of autophagy, thus contributing to DLBCL progression. The gene discussed is PRKN; the disease is diffuse large B-cell lymphoma.