BECN1 and acute lymphoblastic leukemia: A transcript variant of the Beclin 1 gene carrying a deletion of exon 11, which encoded a C-terminal truncation of the Beclin 1 isoform, has been identified in the ALL 697 cell line, while this truncated Beclin 1 isoform displayed a reduced activity in induction of autophagy by starvation, indicating that it might function as a dominant negative modulator of autophagy [82].