Zhang et al. demonstrated that transglutaminase TG2 and nuclear factor-κB (NF-κB) signaling coordinates the survival of MCL cells via IL6-mediated autophagy [105], while Chen et al. demonstrated that ROS-induced C-X-C motif chemokine receptor 4 (CXCR4)/stromal cell derived factor 1 (SDF-1) signaling stimulates autophagy in MCL cells, promoting their survival in the bone marrow microenvironment [106]. The gene discussed is CXCR4; the disease is mantle cell lymphoma.