The mechanism by which MYCN influences NB development was investigated in a study that analysed the transcriptomic profile, specifically miRNA and mRNA interactions implicated in tumourigenesis, of premalignant sympathetic ganglia and tumours from tyrosine hydroxylase promoter-driven MYCN (TH-MYCN+/+) transgenic mice [28]. The gene discussed is MYCN; the disease is neoplasm.