MYC and familial pancreatic carcinoma: In turn, MTSS1-AS repressed the MZF1-mediated transcription of MYC, thereby forming a negative feedback loop between MTSS1-AS and MYC in acidic pancreatic cancer cells, with overexpression or knockdown of MTSS1-AS leading to the inhibition or promotion of MYC expression, respectively (Figure 3B, MTSS1-AS, MTSS1, and MZF1 are lncRNAs encoded by gene A-AS, gene A, and regulatory protein, respectively).