VDAC1 and amyotrophic lateral sclerosis: Remarkably, the use of VDAC1 oligomerization inhibitor VBIT-4 decreased the release of fragmented oxidized mtDNA and inflammation in a mouse model of systemic lupus erythematosus [61] as well as in amyotrophic lateral sclerosis (ALS) patient iPSc-derived motor neurons, suggesting a potential therapeutic approach for these diseases [51].