Indeed, whereas DSCAM interacts with Unc5c (uncoordinated 5) to mediate growth cone collapse and repulsion through the assembly of an intracellular signaling complex involving FYN, FAK, and PAK1 [44], DSCAM also collaborates with DCC (deleted in colorectal cancer) to mediate Netrin-1-induced axon outgrowth and attraction [45,46]. This evidence concerns the gene DSCAM and colorectal cancer.