Compared with the control group, Li et al. have found that 112 circRNAs were up-regulated and 51 circRNAs were down-regulated in AD patients [17], which also were enriched in AD-related pathways, and the clinical guidance of circ-AXL, circ-GPHN and circ-PCCA in disease management of AD patients was identified. The gene discussed is PCCA; the disease is Alzheimer disease.