Since the individuation of this channel in prostate cancer cells [16], numerous studies have confirmed the dysregulation of TRPM8 in the plasma of cancer cells in breast [87], bladder [88], esophageal [89], lung [90], human osteosarcoma [91], skin, pancreas, colon, and other gastric cancers [92]. The gene discussed is TRPM8; the disease is prostate carcinoma.