Uterine leiomyomas display great genetic complexity, ranging from germinal mutations that predispose women to developing uLM, to somatic alterations such as point mutations in the MED12 gene or copy number variants and chromosomal aberrations that affect different regions, to epigenetic alterations, which complicates the utilization and interpretation of multi-omic information related to these tumors. The gene discussed is MED12; the disease is uterine corpus leiomyoma.