Altered expression of this protein, which is involved in transcription regulation, has been associated with leiomyoma development through different mechanisms including angiogenesis [92], ERα-mediated cell proliferation [93], and homologous recombination DNA repair, since one of the preferential translocation partners of HMGA2 is the DNA repair gene RAD51B [94,95]. The gene discussed is HMGA2; the disease is leiomyoma.