While these deletions alter expression of several genes such as LHFPL3, LAMB1, or HPB1 [100,101,102], one of the most accepted target genes is CUX1. 7q deletions can result in both increased and reduced expression of CUX1, suggesting a tumor suppressor or oncogenic role [103,104] that may cause uLM development in a process similar to RAD51B [105]. The gene discussed is CUX1; the disease is neoplasm.