After neoplasia occurs, more bone marrow-derived monocytes from the blood vessels are recruited to the site of the tumor, where they secrete growth factors and chemokines such as CCL2, CCL5, vascular endothelial growth factor (VEGF), and transforming growth factor beta (TGF-β) [44,46,47]. The gene discussed is TGFB1; the disease is neoplasm.