IL4 and neoplasm: In contrast, under the induction of interleukin-4 (IL-4), interleukin-10 (IL-10), interleukin-13 (IL-13), or glucocorticoid-induced differentiation, M2 macrophages secret anti-inflammatory cytokines such as IL-10 and interleukin-1β (IL-1β), and promote angiogenesis, tissue remodeling, injury repair, and tumor initiation and progression [18].