TAMs release a wide range of cytokines, such as VEGF, IL-1, interleukin-8 (IL-8), TNF-α, and matrix metalloproteinase (MMP), which synergistically regulate endothelial cells, matrix remodeling, and vascularization in a spatio-temporal manner in CRC angiogenesis [77,78]. Here, VEGFA is linked to colorectal carcinoma.