The significant decrease in the mRNA levels of MFAP2 in HT-29 cells preincubated with the adipocyte-derived factors obtained from volunteers with OB strengthens the concept of the interaction between adipocytes and tumoral cells and the contribution of adipocytes promoting a microenvironment favourable to tumour progression probably by inducing inflammation and modifying cancer cell behaviour. This evidence concerns the gene MFAP2 and neoplasm.