PTGS2 and neoplasm: Since MAGP-1 sequesters active TGF-β in the ECM, the increased levels of TGFB1 after the stimulation with MAGP-1 may constitute a compensatory mechanism with higher concentrations of MAGP-1 being able to reduce the expression of TGFB1. COX2 is commonly upregulated in diverse tumour types, including CC, promoting cell division and proliferation, apoptosis avoidance and angiogenesis [47].