Additionally, although some genes were found differentially modulated either in HT-29 or SW620 CRC cell lines upon YY1-KD, only one gene, the pro-apoptotic BCL2L15—selectively expressed by HT-29 and SW620—was strongly and significantly downregulated in both YY1-KD clones of both responder CRC cells (Figure 3, Supplementary Figures S2 and S3). Here, YY1 is linked to colorectal carcinoma.