For instance, to assess the significance of the Tau aggregation process in tauopathy, a pro-aggregation C. elegans model overexpressing human TauΔK280 was examined in parallel with another transgenic line co-expressing anti-aggregation substitutions I277P and I308P of Tau that prevent β-sheet formation and subsequent aggregation (human TauΔK280, plus I277P and I308P) [59]. Here, MAPT is linked to tauopathy.