LGALS4 and tauopathy: Using Elav-GAL4/UAS-WT or hTauR406W Drosophila tauopathy models, nicotinamide mononucleotide (NAD) adenylyl transferase (NMNAT) were shown to be involved in a neuroprotective role of rescuing TauR406W mutant phenotypes by clearing toxic phosphorylated Tau proteins and facilitating proper neuronal function [122].