Among them, there are 17 Thr-Pro or Ser-Pro motifs that are abnormally hyperphosphorylated in AD and other Tauopathies [36], and the phosphorylation of Tau at Tyr394 and Tyr18 is detected in paired helix filaments (PHFs) in the brains of AD patients [37]. Here, MAPT is linked to tauopathy.