MAPT and tauopathy: This genome-wide genetic screening strategy can be modified by beginning the screening with a Drosophila genome-wide UAS-miRNA library followed by another RNAi screening for a selected set of identified miRNA-targets, yielding an E3/E4 ubiquitin ligase UBE4B as a novel tauopathy modifier to clear accumulated wild type Tau protein through autophagy [92].