More specifically, a genetic modifier RNAi screening designed to validate AD susceptibility genes have identified cindr, fit1/2, and aret, the fly orthologs of the human CD2AP, FERMT2, and CELF1, respectively, as Tau modifiers implicated mainly in cell adhesion, together with identification of ITGAM and ITGA9, a fly homolog of the human integrin adhesion receptors [152]. Here, MAPT is linked to Alzheimer disease.