EGF and breast carcinoma: Importantly, STAT3 signaling pathways, activated through many cytokines (such as Interleukin-6 (IL-6), IL-10) and growth factors (epidermal growth factor (EGF), fibroblast growth factor (FGF), insulin-like growth factor (IGF)), promote breast cancer progression, proliferation, apoptosis, metastasis and chemoresistance [3].