High-risk human papillomavirus (HPV), whose oncogenes encode well-characterized inhibitors of p53 and Rb, has been detected in up to 18% of OA sebaceous carcinomas without concurrent tumor suppressor mutations, and additional studies have demonstrated overexpression of miRNAs that influence the p53 suppressor complex [6,11,20,21,22]. This evidence concerns the gene TP53 and sebaceous adenocarcinoma.