High-risk human papillomavirus (HPV), whose oncogenes encode well-characterized inhibitors of p53 and Rb, has been detected in up to 18% of OA sebaceous carcinomas without concurrent tumor suppressor mutations, and additional studies have demonstrated overexpression of miRNAs that influence the p53 suppressor complex [6,11,20,21,22]. The gene discussed is RB1; the disease is sebaceous adenocarcinoma.