A potential epigenetic driver of sebaceous carcinoma was observed in the current study, as 4/12 (25%) of all sebaceous carcinomas harbored mutations in KMT2C, or lysine methyltransferase 2C, with 2/2 OA tumors harboring missense mutations and 2/2 extraocular tumors harboring deletions. Here, KMT2C is linked to sebaceous adenocarcinoma.