APOE and atherosclerosis: In our analysis, atherosclerosis development in HFD-fed AAV-Ren/Ang-injected ApoE−/− mice on the C57BL/6J genetic background was accelerated compared to ApoE−/− mice injected with empty vector; however, AAV-Ren/Ang ApoE−/− and ApoE−/− mice on the atherogenic diet showed no differences in serum cholesterol and triglyceride or body weight, indicating that these parameters did not influence the observed difference in atherosclerosis development.