SIGMAR1 and Parkinson disease: A role for Sigma1R has also been described in dendritic spine arborization, branching, and motility in neuronal communication and in synaptic activity (spine density, morphology) for mitigating cognitive deficits associated with Parkinson’s, schizophrenia, autism, obsessive-compulsive disorder (OCD), mental retardation, and Alzheimer’s [28,49,66,106].