Intracellularly, Sigma1R mobilizes calcium stores and modulates neurotransmitters, trophic factors, and ion channels at the level of the plasma membrane [49,62,63,64,65] It is important to note that for consideration of epilepsy, the Sigma1R was described as binding to the NMDA receptor and the G-protein−coupled receptors among other client proteins, which is of critical importance to epilepsy and seizures (Figure 2). This evidence concerns the gene SIGMAR1 and epilepsy.