SIGMAR1 and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: The observation that administration of fenfluramine remediated cognitive deficits in mouse models via Sigma1R activity paralleled clinical findings showing that fenfluramine treatment resulted in clinically meaningful improvements in executive function over time in children and young adults with Dravet syndrome or Lennox-Gastaut syndrome [12,14].