SIGMAR1 and Cognitive impairment: A role for Sigma1R has also been described in dendritic spine arborization, branching, and motility in neuronal communication and in synaptic activity (spine density, morphology) for mitigating cognitive deficits associated with Parkinson’s, schizophrenia, autism, obsessive-compulsive disorder (OCD), mental retardation, and Alzheimer’s [28,49,66,106].