SIGMAR1 and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: Taken together, these results suggest that a positive modulator of Sigma1R can interact with an endogenous Sigma1R agonist to reverse learning and memory impairment, revealing an intriguing new avenue of research for Sigma1R in mediating both seizures and non-seizure learning deficits in models of Dravet syndrome.