Sigma1R-mediated neuroprotection and antiapoptosis are mechanisms implicated in multiple neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, stroke, and amyotrophic lateral sclerosis (ALS)/frontotemporal dementia [69], as well as in retinal neurodegeneration [110]. This evidence concerns the gene SIGMAR1 and early-onset autosomal dominant Alzheimer disease.