ANGPTL2 and colorectal carcinoma: In a different paper, the same authors [37] revealed that knockdown of the ANGPTL2 gene significantly inhibits cell proliferation, migration, and invasion, but enhances apoptosis in vitro, and high ANGPTL2 expression and/or serum concentration can be associated with advanced T stage, lymph node, liver metastasis, early relapse, and poor CRC prognosis.