Despite prostasomes (EVs secreted by epithelial cells in the prostate gland) being considered the most accurate sources for proteomic or transcriptomic biomarker discovery in PC, to date only one study has reported that metastatic PC tissues release EVs, displaying altered annexins A1, A3, A5, and dimethylarginine dimethylaminohydrolase 1 expression [116]. This evidence concerns the gene DDAH1 and pachyonychia congenita.