In a follow-up study, the score provided by assaying PCA-3, ERG, and SPDEF gene expression in urine EVs (ExoDx Prostate IntelliScore) outperformed standard of care values, discriminating PC patients with ≥GS7 from GS6 or with a negative biopsy (AUC = 0.73). Here, ERG is linked to pachyonychia congenita.