GGTase-I produced from the expression of protein geranylgeranyltransferase type I subunit beta (PGGT1B) gene is associated to diabetes-accelerated atherosclerosis, and removal of PGGT1B gene in mice shown attenuated phenotype of diabetes-accelerated atherosclerosis with possible involvement of several mechanisms that inhibit VSMC proliferation [133]. The gene discussed is PGGT1B; the disease is atherosclerosis.