Down-regulation of other gene targets such as ANGPTL8, FMO3, and STXBP5 were also modeled in mice and displayed impaired lipogenesis with reduced body weight and plasma triglyceride levels [130], reduced thrombosis potential and atherosclerosis [131], and lowered plasma von Willebrand factor (VWF) levels with reduced thrombosis [132]. Here, VWF is linked to atherosclerosis.