Furthermore, by using an influenza-A model, Xie et al. [80] showed that all activated human T cells co-expressed IL-17 and granzyme B. Th17 cells are critically important for protective immunity of mucosal surfaces against fungal infections and extracellular bacteria but are also implicated in the pathology of several inflammatory and autoimmune diseases [81]. This evidence concerns the gene GZMB and autoimmune disease.